VOA标准英语2012--Researchers Say Malaria Drug Could Also Treat Cancer

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The spread of cancer is accelerated by the death of these cells.

“This process called autophagy, which literally³ means to self-eat, is present in all cells," said Dr. Ravi Amaravadi. "But what we are finding in our research is that cancer cells have a very high level of autophagy even before any treatment, and so they are poised⁴ to take on the damage from existing cancer therapies and simply break down the damaged parts to fuel further growth.”

Dr. Ravi Amaravadi spoke⁵ to us via Skype. He is a cancer specialist at the University of Pennsylvania School of Medicine. His group treated patients by combining conventional cancer medications with the anti-malarial drug, hydroxychloroquine. The compound is known to inhibit⁶ autophagy and researchers hoped it could stop cancer cells from growing.

In clinical trials, scientists found that hydroxychloroquine paired poorly with some cancer drugs. But it worked well with others, such as Temsirolimus, in helping⁷ to halt tumor² growth - a so-called "stable disease" rate - in patients with melanoma, an aggressive skin cancer. 

“And when Temsirolimus [a cancer drug] was tested in melanoma, it had zero percent stable disease rate," said Amaravadi. "And when we combined with hydroxychloroquine malaria drug, the stable disease rate went up to 76 percent so that’s a very big difference.”

Researchers used a high dose of hydroxychloroquine to block autophagy, much higher than what's normally used to treat rheumatoid arthritis⁸ or malaria. The dosage has not yet proved harmful. 

Dr. Davide Ruggero at the University of California, San Francisco, is also studying the growth of cancer cells. He says the results of the research with hydroxychloriquine are promising⁹.

“This is a great discovery because we know that the compounds are not toxic¹⁰ - have already been used," said Ruggero.

But Dr. Amaravadi warns that oncologists should not use the anti-malaria drug outside of clinical settings. He says hydroxychloroquine has severe side effects when combined with some cancer drugs. So the knowledge of which compounds work well together is critical. 

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