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美国科学60秒-SSS 2015-06-23

时间:2015-08-21 03:12:14

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 This is Scientific Americans 60 seconds science, I am , got a mimute? probiotics are so hot, bacterial1 that we can consume in food like yoghurt, miso and pickles2 can help us got my grow bands, they are happy and healthy.Now there might be another role for these probiotic bacterial: cancer detection.Two paper in Journal Science Translational Medcine explain how researchers hope to get bacterial to be diagnostic tools.Sangeeta N. Bhatia is liver expert and senior author of one of the papers. Her lab has been trying to figure out how to get nanoparticles to the liver that would sent signal detectable3 in urine and then counter the tumor4.Cancers that start in the core of pancrease can metastasize to the liver witch can be deadly.One of the students in our team had idea that we could imagine there is material, the diagnostic material that would grow itself, and you wouldn't need very much of it to turn out a tumor and concern it safey ? . and we realize that bacterial are in many ways just such device.that they can natually home on tumors.So maybe we can hijack5 that ability of bacterial to home on tumors and self-amplify to creat a urine diagnostic.Bhatia's lab teamed up with a lab at the university of Califonia santiago with expertise6 in synthetic7 biology basically alter microbe to have specific functions.So we just going out to finding nature strains that would colonize8 tumors and do what we want it.We could , em, keep strains that have good homing and then in doubt them with kick dotties (?) that we were interested in. The two labs ? strain of E.coli Nissle that is already used to provide healthy people with digest issue.They programed two bacterials to express specific enzyme9 after occupied liver tumors.If the bacterial colonize the tumor in mice, the mice would produce urine that,thanks to the enzyme, would turn red. The system worked, the bacterial found to tumors in mice to have them and urine changed color indicating a presence of cancer.Cancer-free mice also ate engineered probiotics showed no negtive healthy effect later.The technic is at this stage just proof of concept that Bhatia is got a lot of promises. We are really excited about the idea that you can take synthetic biology someday into both diagnostics and also therapeutics.So in this particular case, the circuitry that we putted into bacterial gave off a diagnostic signal that could be detected remotely.You can also imagine that we are working on circuits they give off killer10 therapy that would kill the tumor directly and in making smart circuits that do that responsive ways.You can even imagine we have mixtures of bacterial that do both diagnose and therapy. So I think there is really a whole world of possibility is once you think about using bacterial as parts of engineered functions.


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1 bacterial dy5z8q     
a.细菌的
参考例句:
  • Bacterial reproduction is accelerated in weightless space. 在失重的空间,细菌繁殖加快了。
  • Brain lesions can be caused by bacterial infections. 大脑损伤可能由细菌感染引起。
2 pickles fd03204cfdc557b0f0d134773ae6fff5     
n.腌菜( pickle的名词复数 );处于困境;遇到麻烦;菜酱
参考例句:
  • Most people eat pickles at breakfast. 大多数人早餐吃腌菜。 来自《简明英汉词典》
  • I want their pickles and wines, and that.' 我要他们的泡菜、美酒和所有其他东西。” 来自英汉文学 - 金银岛
3 detectable tuXzmd     
adj.可发觉的;可查明的
参考例句:
  • The noise is barely detectable by the human ear.人的耳朵几乎是察觉不到这种噪音的。
  • The inflection point at this PH is barely detectable.在此PH值下,拐点不易发现。
4 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
5 hijack KdNxS     
v.劫持,劫机,拦路抢劫
参考例句:
  • Most countries refuse to give sanctuary to people who hijack aeroplanes.大多数国家拒绝对劫机者提供庇护。
  • The hijack take place just after the plane take off.劫持是飞机刚起飞后发生的。
6 expertise fmTx0     
n.专门知识(或技能等),专长
参考例句:
  • We were amazed at his expertise on the ski slopes.他斜坡滑雪的技能使我们赞叹不已。
  • You really have the technical expertise in a new breakthrough.让你真正在专业技术上有一个全新的突破。
7 synthetic zHtzY     
adj.合成的,人工的;综合的;n.人工制品
参考例句:
  • We felt the salesman's synthetic friendliness.我们感觉到那位销售员的虚情假意。
  • It's a synthetic diamond.这是人造钻石。
8 colonize mqzzM     
v.建立殖民地,拓殖;定居,居于
参考例句:
  • Around 700 Arabs began to colonize East Africa.公元700年阿拉伯人开始把东非变为殖民地。
  • Japan used to colonize many countries in Asia.日本曾经殖民过许多亚洲国家。
9 enzyme cPozF     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
10 killer rpLziK     
n.杀人者,杀人犯,杀手,屠杀者
参考例句:
  • Heart attacks have become Britain's No.1 killer disease.心脏病已成为英国的头号致命疾病。
  • The bulk of the evidence points to him as her killer.大量证据证明是他杀死她的。

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