科学美国人60秒 SSS 人类减肥药也能抑制蚊子的食欲

（单词翻译）

This is Scientific American — 60-Second Science. I'm Karen Hopkin.

Believe it or not, mosquitoes don't bite out of spite. Female mosquitoes of the species Aedes aegypti need the nutrients¹ present in your plasma² to ensure the proper development of their eggs. And though their thirst may seem unquenchable, the ladies actually take time to savor³ your blood once they've sipped⁴ their fill.

"After a female bites, she'll double her body weight, and then she'll actually completely lose interest in biting people for several days."

Laura Duvall, a postdoctoral researcher at The Rockefeller University in New York City. The insects' postprandial recovery phase made Duvall and her colleagues wonder whether they could essentially⁵ trick mosquitoes into thinking they'd already eaten.

Duvall works in the lab of Leslie Vosshall, who studies genetics, neuroscience and behavior. Here's Vosshall:

"Our idea was that maybe the same drugs that would t?urn⁶ off human appetite might actually work to turn off mosquito appetite."

Turns out that when the Rockefeller researchers fed mosquitoes a drug used to treat people for obesity⁷, the insects were indeed less interested in hunting for their next human meal ticket.

"But the problem was we needed to figure out how the human diet drugs were actually working in the mosquito."

So they isolated⁸ the receptor protein with which these diet drugs interact. The receptor...which they dubbed⁹ NPYLR7...looks a lot like the receptors that regulate hunger in people.

The researchers knew they had the right receptor because, when they knocked it out in some mosquitos, the drugs no longer dampened the insects' appetite...a finding they describe in the journal Cell.

In fact, the mutant mosquitoes were all-around insatiable.

"So the npylr7 mutants behave really strangely. Even after they take a huge blood meal, they remain thirsty for human blood."

Next, Duvall says they'd like to explore exactly how these drugs act to curb¹⁰ a female's blood lust¹¹.

"Does she become less sensitive to the clues that tell her a human is nearby? Or is this like smelling a hamburger after you've already eaten three?"

Either way, the approach could provide a novel method to limit the spread of diseases transmitted by mosquito bite, like dengue and yellow fever. And give us a new way to tell mosquitoes to buzz off.

Thanks for listening for Scientific American — 60-Second Science. I'm Karen Hopkin.