SSS 2011-07-01
时间：2011-08-09 03:07:37
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（单词翻译）
This is Scientific American's 60 second science. I'm Steve Mirsky. At the Lindau Nobel Laureate Meeting at Lindau Germany. This will just take a little bit more time than our usual may?. Edmond Fischer won the Nobel Prize in Physiology1 of Medicine in 1992 for his discoveries with Edwin Krebs about the way proteins get activated2 and cellular3 processes get regulated via a simple process called phosphorylation. Now 91 years old, Fisher spoke4 to students at the Lindau Nobel Laureate Meeting about the difference between research when he was working in the 1950s and the way it's conducted today.
Science was conducted in a totally different way. In those days, in fact since the days of Claude Bernard, the Frech
physiologist5 who first showed the glycogenic action of the pancreas, when observed a
physiological6 phenomenon, and then one try to detect the factors,
enzymes8,
hormones9 responsible for it whereas today, by and large, you see other way around. First
enzyme7 proteins are discovered, then with the completion of I don't know how many geno sequencing projects, hundreds are being discovered. And then by overexpressing them, knocking them in and out, one tries to determine their function. So to
paraphrase10 B D, we went from 6 functions in search of an enzyme, to hundreds of enzymes and protein in search of a function.
Thanks for the minutes, for Scientific American's sixty second science from the Lindau Nobel Laureate meeting. I'm Steve Mirsky.
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