SSS 2012-08-14
时间：2013-01-06 08:39:21
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（单词翻译）
Five-hundred years ago, a 15-year-old Incan girl was sacrificed, along with two other children. Her mummy has now revealed that she had an active lung infection at her death. Because a technique called shotgun proteomics has been used to determine whether someone was actually suffering from a disease rather than just carrying it. The report appears in the journal PLoS ONE. [Angelique Corthals et al., Detecting the Immune System Response of a 500-Year-Old Inca Mummy]
Previous research into ancient diseases has used
DNA1 analysis to determine the presence of pathogens. But with DNA, there's no way to tell latent infections from the full-blown, misery-inducing ones.
Researchers
analyzed2 protein samples from the mummies of two of the
slain3 children. The girl's proteins indicated an immune response to bacteria, perhaps a pathogen related to
tuberculosis4. Other evidence, such as mucus under her nose and lung abnormalities, strengthened the
diagnosis5. The seven-year-old boy, on the other hand, showed no signs of infection.
This is the first time the technique has been used. It’s a small sample, but further development of shotgun proteomics has the potential to improve our understanding of ancient disease, as well as assisting in tomorrow’s
forensic6 investigations7.
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