科学美国人60秒 SSS 2014-03-14

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The pain relieving effects of drugs like ibuprofen are well known. But ibuprofen and its relatives, known as nonsteroid anti-inflammatory drugs, may someday have another use: as antibiotics¹. Researchers tested three anti-inflammatory drugs: bromfenac, used in eye drops; and carpfonen and wedeproofen, both for treating conditions like arthritis² in dogs. The investigators³ found that all three drugs bind⁴ to something called the DNA⁵ clamp(?) in bacteria. That clamp is essential to repairing and replicating⁶ DNA. By jamming it, the painkillers⁷ can actually kill live cola(?) in a test tu... at least. The finding appears in the journal Chemistry & Biology. Study author Ahron Oakley of Australia University of Wollengong says we still need clinical trials to tell if this trick holds true in humans. But this study is a first step. "This is to alert a lot of technicians to the fact some of the nonsteroidal ... they using may have this targeted effect." It gives drug developers, like Oakley and his colleagues, a whole new way to attack antibiotic-resistant bacteria.

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