美国科学60秒 SSS 2015-05-29

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Scientists jabbed hypertensive rates with three doses of the formulation. It's a DNA² vaccine, containing DNA fragments from angiotensin II—a hormone³ that boosts blood pressure as well as fragments from hepatitis B, to guarantee the immune system's attention. Cells suck up the vaccine's DNA and start pumping out the proteins the DNA codes for. When the host's defenses get a whiff (a smell that is only smelled briefly⁴ or faintly) from the proteins, it reacts. It really revs⁵ up (make or become active or energetic) against the hepatitis B fragments, and while it's at it, it starts taking out some angiotensin II as well. 

 

The result is a reduction of angiotensin II's usual blood raising effect, similar to what blood pressure meds like Benicar do. Less angiotensin II means more relaxed blood vessels⁶ and a drop in pressure. That effect lasted six months in the vaccinated⁷ rats, and lengthened⁸ their lifespan by eight weeks. Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to the kidneys or livers. The results are in the journey Hypertension. 

 

Other blood pressure vaccines⁹ have been tried, unsuccessfully, but this naval¹⁰ DNA-based vaccine could induce (bring about or give rise to) longer-lasting effect, and the hope of twice yearly shot instead of daily pills. 

 

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