世卫宣布埃博拉疫苗试验成功

搜索关注在线英语听力室公众号：tingroom，领取免费英语资料大礼包。

　　The World Health Organization said Friday that the vaccine has so far been 100 percent effective in trials conducted in Guinea. The British medical journal Lancet has published preliminary results and analyses.

　　The new vaccine "may be the silver bullet against Ebola," said B?rge Brende, the foreign minister of Norway, one of several countries involved in the trials.

　　The Ebola outbreak that swept through West Africa last year has killed more than 11,000 people, most of them in Liberia, Guinea and Sierra Leone.

　　WHO: Ebola Vaccine Promising²

　　Ebola is one of a number of highly dangerous viruses known as hemorrhagic fevers. There are hopes the new vaccine may be a breakthrough in combating all such diseases.

　　The vaccine, known as VSV-EBOV, was tested beginning in March on more than 4,000 people in Guinea who had come into close contact with the Ebola virus.

　　Initial results were so promising that random³ trials were stopped this week so everyone at risk could receive the vaccine immediately, WHO said.

　　“These are the first results. ... They need to be further looked into and we need to still collect more data on the vaccine, " noted⁴ John-Arne R?ttingen, director of the Division of Infectious Disease Control at the Norwegian Institute of Public Health, which conducted clinical trials of the vaccine in Guinea.

　　"There is no licensed⁶ vaccine we are looking at at this time. So that means the best way we can secure continued access to the vaccine in Guinea is to continue the trial," he told VOA. "That would both give us the opportunity to collect more evidence, but it will also give access to those of highest risk of Ebola in Guinea.”

　　'Game changer'

　　Margaret Chan, WHO's general director, told reporters in Geneva that scientists, doctors, donors⁷ and drug companies collaborated⁸ in development of the vaccine.

　　"If proven effective, this is going to be a game changer, and it will change the management of the current Ebola outbreak and future outbreaks," Chan said at a news conference.

　　Because of the shifting nature of the epidemic⁹ and a sharp drop in the number of new Ebola cases in Africa in the past few months, researchers switched their tactics as they began the drug trial.

　　What had been a generalized outbreak expanding extremely rapidly last year switched to a series of sudden, small outbreaks across the region.

　　The “gold standard” for testing a new drug would call for vaccinating¹⁰ half of a population at risk of contracting Ebola, while giving other people in the virus zone a placebo¹¹.

　　Instead, the team working on the new vaccine used a “ring” design.

　　When a first Ebola case occurred in a village, researchers vaccinated¹² everyone in contact with the sick person.

　　Such "rings" of vaccination¹³ took place either immediately after an Ebola infection was confirmed or three weeks later, according to the researchers' random assignments.

　　Vaccinations¹⁴

　　Of 2,014 people vaccinated immediately, no one had contracted Ebola when tested 10 days after receiving the new drug. In the clusters where people were vaccinated three weeks later – 2,380 people – 16 people contracted the virus.

　　Trial data will now go to regulatory agencies to obtain a license⁵ for the vaccine which will allow it to be developed in bulk for future Ebola epidemics¹⁵.

　　There have been a total of 27,748 cases of Ebola in Guinea, Liberia and Sierra Leone, with 11,279 reported deaths. The outcome of many cases is not yet known, however, and the eventual¹⁶ full toll¹⁷ like will be significantly higher.

分享到：