TED演讲:抗击癌症的新式武器(3)

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and silence those survival genes², and then we'll whop it with a chemo drug. 让（癌细胞的）生存基因失效，然后我们再用化学药品来对付癌细胞。

But how do we carry that out? 但如何实现呢？

Using molecular³ engineering, we can actually design a superweapon that can travel through the bloodstream. 答案是分子工程技术，我们可以设计一种超级武器，能在血液循环中存活下来。

It has to be tiny enough to get through the bloodstream, it's got to be small enough to penetrate⁴ the tumor⁵ tissue, 它必须足够小，才可以进入血液循环，它必须足够小，才可以穿过肿瘤组织，

and it's got to be tiny enough to be taken up inside the cancer cell. 它必须足够小，才可以进入癌细胞内部，

To do this job well, it has to be about one one-hundredth the size of a human hair. 要做到这一点，它的尺寸必须小到头发的百分之一。

Let's take a closer look at how we can build this nanoparticle. 来仔细看一下我们是如何制造这种纳米粒子的。

First, let's start with the nanoparticle core. 首先，我们要制造纳米核。

It's a tiny capsule that contains the chemotherapy drug. 那是一颗小胶囊，内含化学药剂。

This is the poison that will actually end the tumor cell's life. 对肿瘤细胞而言是致命毒药。

Around this core, we'll wrap a very thin, nanometers-thin blanket of siRNA. This is our gene blocker. 在内核周围，我们包上一层很厚的--当然也就几纳米厚的siRNA。这是我们的基因拦截者。

Because siRNA is strongly negatively charged, 因为siRNA带负电，

we can protect it with a nice, protective layer of positively⁶ charged polymer. 我们用一层坚固的，带正电的聚合物来保护它。

The two oppositely charged molecules⁷ stick together through charge attraction, 这两种带有不同电荷的分子相互吸引，

and that provides us with a protective layer that prevents the siRNA from degrading in the bloodstream. We're almost done. 形成一层保护膜，防止siRNA在血液中被降解。别着急，我快说完了。

 

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