纪录片《长生不老》 25破坏性蛋白质的产生

（单词翻译）

It's now been discovered that progeria

经实验发现早衰症

is caused by a mutation¹ in a gene² called lamin A.

是由一种叫核纤层蛋白A变异引起的

This leads the body to produce an abnormal protein

这种蛋白使那些患病小孩体内的细胞

within these children's cells

产生一种异常蛋白质

which blocks their normal functioning.

阻碍细胞的正常功能

What's interesting about the disease

这种疾病有趣的地方是

is that the same abnormal protein

这种异常蛋白质

is also made at very, very low levels

在那些没有发生变异的健康人身上

in healthy individuals who do not have the mutation.

产生的概率是非常非常低的

The level of this abnormal protein

这种蛋白质异常的状况

doesn't increase over time as we age,

不会随着我们年龄的增长而增加

but what seems to happen is that

但是看起来

cells from old individuals are not able to

老年人体内的细胞抵抗

cope with this protein any more which is trying to do damage.

这种破坏性蛋白质的能力会弱些

Other proteins also go wrong

随着年龄的增长 其他细胞也会出现病变

and as we get older we have more difficulty repairing the damage.

那时 自我修复的功能就会越来越差

Dr Misteli believes this build-up of damaged protein

米斯泰林博士觉得这种破损性蛋白质的产生

within our cells could be at the heart of how we all age.

可能就是我们如何衰老的根本原因