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U.S. researchers discover human lung stem cell

时间：2011-05-12 08:19:04

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     WASHINGTON, May 11 (Xinhua) -- Researchers at Brigham and Women 's Hospital (BWH), a teaching affiliate1 of Harvard Medical School, have identified(鉴定) a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung. This research will be published Thursday in the New England Journal of Medicine.

    "This research describes, for the first time, a true human lung stem cell. The discovery of this stem cell has the potential to offer those who suffer from chronic2 lung diseases a totally novel treatment option by regenerating3 or repairing damaged areas of the lung," said the study's corresponding author Piero Anversa, who is also director of the Center for Regenerative Medicine at the hospital.
    Using lung tissue from surgical4 samples, researchers identified and isolated6 the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated7 into new bronchioles, alveoli and pulmonary vessel8 cells which not only formed new lung tissue, but also integrated structurally9 to the existing lung tissue in the mice.
    The researchers define this cell as truly "stem" because it fulfills10 the three categories necessary to fall under stem cell categorization: first, the cell renews itself; second, it forms into many different types of lung cells; and third, it is transmissible, meaning that after a mouse was injected with the stem cells and responded by generating new tissue, researchers were then able to isolate5 the stem cell in the treated mouse, and use that cell in a new mouse with the same results.
    "These are the critical first steps in developing clinical treatments for those with lung disease for which no therapies exist. Further research is needed, but we are excited about the impact this discovery could have on our ability to regenerate11 or recreate new lung tissues to replace damaged areas of the lungs," said Joseph Loscalzo, chair of the Department of Medicine at BWH and co-author.(本文由在线英语听力室整理编辑)

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1 affiliate TVBzj     
vt.使隶(附)属于；n.附属机构，分公司
参考例句：
  • Our New York company has an affiliate in Los Angeles.我们的纽约公司在洛杉矶有一个下属企业。
  • What is the difference between affiliate and regular membership?固定会员和附属会员之间的区别是什么？
2 chronic BO9zl     
adj.(疾病)长期未愈的，慢性的；极坏的
参考例句：
  • Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
3 regenerating 0fd51be890ff4b873643d13907e3ab4f     
v.新生，再生( regenerate的现在分词 )；正反馈
参考例句：
  • It is not proposed to deal with the detailed histology of regenerating tissues here. 这里未提出详细的再生组织的组织学。 来自辞典例句
  • This is accomplished by using a thermocompressor to recycle regenerating steam through the absorber. 它用热压机使再生蒸汽经吸附器循环完成解吸过程。 来自辞典例句
4 surgical 0hXzV3     
adj.外科的，外科医生的，手术上的
参考例句：
  • He performs the surgical operations at the Red Cross Hospital.他在红十字会医院做外科手术。
  • All surgical instruments must be sterilised before use.所有的外科手术器械在使用之前，必须消毒。
5 isolate G3Exu     
vt.使孤立，隔离
参考例句：
  • Do not isolate yourself from others.不要把自己孤立起来。
  • We should never isolate ourselves from the masses.我们永远不能脱离群众。
6 isolated bqmzTd     
adj.与世隔绝的
参考例句：
  • His bad behaviour was just an isolated incident. 他的不良行为只是个别事件。
  • Patients with the disease should be isolated. 这种病的患者应予以隔离。
7 differentiated 83b7560ad714d20d3b302f7ddc7af15a     
区分，区别，辨别( differentiate的过去式和过去分词 )； 区别对待； 表明…间的差别，构成…间差别的特征
参考例句：
  • The development of mouse kidney tubules requires two kinds of differentiated cells. 小鼠肾小管的发育需要有两种分化的细胞。
  • In this enlargement, barley, alfalfa, and sugar beets can be differentiated. 在这张放大的照片上，大麦，苜蓿和甜菜都能被区分开。
8 vessel 4L1zi     
n.船舶；容器，器皿；管，导管，血管
参考例句：
  • The vessel is fully loaded with cargo for Shanghai.这艘船满载货物驶往上海。
  • You should put the water into a vessel.你应该把水装入容器中。
9 structurally b9ab462aabf667bfba00ea360ed6c929     
在结构上
参考例句：
  • The house roof was (structurally) unsound. 这屋顶（结构）不牢固。
  • Pinhole on shot-hole damage is never structurally significant. 针孔和蛀洞所造成的危害对结构的影响不大。
10 fulfills 192c9e43c3273d87e5e92f3b1994933e     
v.履行（诺言等）( fulfill的第三人称单数 )；执行（命令等）；达到（目的）；使结束
参考例句：
  • He always fulfills his promises. 他总是履行自己的诺言。 来自辞典例句
  • His own work amply fulfills this robust claim. 他自己的作品在很大程度上实现了这一正确主张。 来自辞典例句
11 regenerate EU2xV     
vt.使恢复，使新生；vi.恢复，再生；adj.恢复的
参考例句：
  • Their aim is to regenerate British industry.他们的目的是复兴英国的工业。
  • Although it is not easy,you have the power to regenerate your life.尽管这不容易，但你有使生活重获新生的能力。

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