【英语时差8,16】靠基因修复牙齿珐琅质

Don: Time to go again to the A Moment of Science mailbox. A listener writers:

Dear Don and Yaël, 

I've had a problem with cavities all my life, so I'm wondering if there are any new dental techniques or discoveries that can help me prevent tooth decay?

Yaël: Good question. The answer is that the best way to prevent cavities is regular flossing and brushing, and regular trips to the dentist.

D: Right. But dental researchers do have investigations¹ in the works that could usher² in a new era of treating and preventing cavities. For example, scientists at Oregon State  have identified the gene³ that controls how our bodies grow tooth enamel⁴--the super hard coating that gives our teeth their strength and chewing power. It's a cool discovery because it could lead to techniques that allow dentists to repair damaged enamel and maybe even re-grow damaged teeth.

Y: Right, but let's give a little context, Don. The researchers studied the gene, called C-tip 2, by turning it off in embryonic⁵ mice. They found that the developing mouse embryos⁶' teeth lacked enamel. So the gene is necessary for producing enamel.

D: The important thing is that knowing the genetic⁷ basis of tooth enamel could lead to new dental treatments. For example, most cavities are due to holes in enamel that  allow decay to happen.

 So scientists could one day be able to use teeth stem cells to grow new enamel. This could be especially useful for people whose enamel has been worn away due to diet or other factors.

Y: Stem cell enamel replacement⁸ is a long way off, but discovering an enamel gene is a pretty good first step in that direction.