SSS 2010-05-27

（单词翻译）

This is Scientific American's 60-Second Science, I'm Steve Mirsky. Got a minute?

A strain of mutant mice groom¹ compulsively till they seriously injure themselves. The condition is considered a good animal model for OCD, and it’s similar to the human disorder² trichotillomania, where people pull out their own hair. Now researchers have successfully treated this pathological behavior in the mice—with a bone marrow³ transplant. The work, led by Nobel Laureate Mario Capecchi, was published in the journal Cell.

The mouse condition is related to immune system cells called microglia. These cells originate in the bone marrow and wind up in the brain, where their job is to fight off infections. But a genetic⁴ mutation⁵ leads to defective⁶ microglia, which drive the mice to perform the odd, self-mutilating behavior.

The researchers gave 10 mutant mice bone marrow from healthy mice. And the presence of normal microglia stopped the compulsion. It’s compelling evidence for the long-proposed link between the immune system and certain psychiatric disorders⁷.

Capecchi warns that bone marrow transplants are too risky⁸ to be commonly used against, for example, OCD. Rather, a fuller understanding of the immune system-mental illness connection should produce new treatments.

Thanks for the minute for Scientific American’s 60-Second Science. I’m Steve Mirsky.